Chimeric lysin
WebDec 1, 2024 · With the increasing spread of multidrug-resistant bacterial pathogens, it is of great importance to develop alternatives to conventional antibiotics. Here, we report the generation of a chimeric phage lysin, MLTphg, which was assembled by joining the lysins derived from Meiothermus bacteriophage MMP7 and Thermus bacteriophage TSP4 with … WebMar 29, 2024 · Chimeric lysin candidates were created through fusion with various enzymatic and cell-wall-binding domains based on LysK lysin, autolysins and lysostaphin …
Chimeric lysin
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WebFeb 10, 2024 · The control was performed without chimeric lysin. (A) Changes in total viable counts in the chilled chicken during storage at 4 °C for 14 days. (B) Changes in the pH of the chilled chicken during ... WebApr 19, 2024 · In this study, a novel chimeric lysin, ClyC, was constructed by fusing the CD from the Ply187 lysin with the CBD from the LysSA97 lysin. The CD of Ply187 …
WebNov 4, 2013 · The chimeric lysin ClyH was constructed by fusing the N-terminal 157 amino acids of Ply187 (Pc) with the C-terminal 97 amino acids of phiNM3 lysin. To do this, the DNA fragment encoding the chimeric lysin was chemically synthesized by Songon Biotech (Shanghai, China). WebNational Center for Biotechnology Information
WebJan 9, 2024 · Yang, H. et al. Novel chimeric lysin with high-level antimicrobial activity against methicillin-resistant Staphylococcus aureus in vitro and in vivo. Antimicrob. Agents Chemother. 58 , 536–542 ... WebMay 25, 2024 · A newly evolved chimeric lysin motif receptor-like kinase in Medicago truncatula spp. tricycla R108 extends its Rhizobia symbiotic partnership. ... Using genomics and reverse genetics, we identified a newly evolved, chimeric LysM receptor-like kinase gene in R108, LYK2bis, ...
WebSep 15, 2014 · Developing chimeric lysins with a wide lytic spectrum would be important for treating some infections caused by multiple pathogenic bacteria. In the present work, a novel chimeric lysin (Ply187N-V12C) …
WebNov 4, 2013 · Similar to other studies [15,26, 33, 34], this activity can be further improved by binding it to the CBD of another lysin to form a novel chimeric lysin. The non-SH3b CBD of LysSA97 has a specific ... scan my flash driveWebJul 20, 2024 · Dental caries is a common disease caused by oral bacteria. Streptococcus mutans and Streptococcus sobrinus are the primary cariogenic microbes that often survive as biofilms on teeth. In this study, we evaluated the activity of ClyR, a well-known chimeric lysin with extended streptococcal host range, against common Gram-positive oral … scan my faceWebMar 29, 2024 · Chimeric lysins composed of various combinations of cell wall-lysing (enzymatic) and cell-wall-binding (CWB) domains of endolysins, autolysins, and bacteriocins have been developed as alternatives to or adjuvants of conventional antibiotics. The screening of multiple chimeric lysin candidates for activity via E. coli expression is not … ruby lips by silvestriWebSep 15, 2014 · In the present work, a novel chimeric lysin (Ply187N-V12C) was constructed by fusing Ply187N with the CBD (146-314aa, V12C) of PlyV12 to test if the lytic specificity of Ply187N would be extended to … scan my files with defenderWebApr 17, 2014 · The chimeric lysin (called ClyS) was obtained by fusing the N-terminal catalytic domain of the S. aureus Twort phage lysin with the C-terminal cell wall-targeting domain from another S. aureus ... rubylions teaWebJan 9, 2024 · A novel chimeric lysin with robust antibacterial activity against planktonic and biofilm methicillin-resistant Staphylococcus aureus Methicillin-resistant Staphylococcus … ruby lipscombWebJan 3, 2024 · Bacteriophage endolysin, also called lysin, is a kind of promising bactericidal component with mechanisms of action fundamentally different from traditional antibiotics. … scan my flash drive online