Witryna25 sty 2024 · Ongoing multinational ORION clinical trials are evaluat-ing the long-term safety and ecacy of inclisiran, as well as its use in adults with homozygous familial … Witryna1 sty 2003 · Methods: In this post hoc analysis from ORION-9 (NCT03397121), ORION-10 (NCT03399370) and ORION-11 (NCT03400800), eligible patients were randomized 1:1 to receive 300 mg inclisiran sodium...
STATISTICAL ANALYSIS PLAN - ClinicalTrials.gov
Witryna3 kwi 2024 · Study 1 (ORION-10, NCT03399370) was a multicenter, double-blind, randomized, placebo-controlled 18-month trial in which 1561 patients with ASCVD were randomized 1:1 to receive subcutaneous injections of either LEQVIO 284 mg (n = 781) or placebo (n = 780) on Day 1, Day 90, Day 270, and at Day 450. ... Witryna15 gru 2024 · The ORION-10 trial ( NCT03399370) included 1561 patients in North America, and the ORION-11 trial ( NCT03400800) included 1617 patients worldwide (non-USA). garrity apartments
†Efficacy and Safety of Inclisiran in Patients with Polyvascular ...
Witryna23 gru 2024 · Purpose Patients with polyvascular disease (PVD) are at very high cardiovascular risk and require intensive lipid-lowering therapy. This analysis describes the lipid-lowering efficacy and safety of inclisiran versus placebo in patients with and without PVD. Methods In this post hoc analysis of the ORION-9, ORION-10, and … Witryna1 mar 2024 · In this post hoc analysis from ORION-9 (NCT03397121), ORION-10 (NCT03399370) and ORION-11 (NCT03400800), eligible patients were randomized 1:1 to receive 300 mg inclisiran sodium (equivalent to 284 mg inclisiran) or placebo at baseline, Day 90 and 6-monthly thereafter. Analysis was stratified by baseline BMI: … Witryna16 lut 2024 · A total of three Phase 3 studies, i.e., the ORION-9 (NCT03397121), ORION-10 (NCT03399370), and the ORION-11 (NCT03400800) trial, two randomized, double-blind, placebo-controlled, parallel-group, were registered [123,172,173]. This was done to determine the efficacy, safety, and adverse-event profile of inclisiran over 18 … garrity blvd nampa