Pyrin aim2
WebMar 25, 2013 · Upon dsDNA engagement, the AIM2 amino-terminal pyrin domain (PYD) is responsible for downstream signaling to the adapter protein apoptosis-associated speck-like protein containing a caspase ... WebDec 9, 2024 · The inflammasome is a molecular platform that drives effector caspase-1 activation, which is assembled by NLRs, AIM2-like receptors (ALRs), or pyrin that can directly or indirectly (via the ...
Pyrin aim2
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WebFeb 24, 2024 · 目前已发现的炎性小体可分为aim2样受体家族的aim2、ifi16、pyrin炎性小体和nod样受体家族的nlrp1、nlrp3、nlrc4、nlrp6、nlrp12炎性小体 ... aim2炎性小体可能成为预测早期nsclc进展和预后判断的一个潜在分子标志物，并且为调控nsclc相关性炎症的免疫调节 … WebAIM2是PHYIN蛋白家族的成员。AIM2主要定位于胞质内，N端含一个PYD结构域（pyrin domain），C端为HIN-200结构域。当AIM2的HIN-200结构域在胞质内结合双链 DNA后，释放PYD而招募接头蛋白ASC，并诱导了炎性小体的组装，从而引起Caspase-1的激活以及IL-1β和IL-18的成熟和分泌。
WebOne of the interferon-inducible proteins, AIM2, is a protein encoded by the AIM2 gene. 16 It consists of two structural domains linked by long junctions: an N-terminal pyrin domain (PYD) and a C-terminal HIN (Hematopoietic, interferon … WebAug 6, 2024 · Author summary Pyrin and HIN domain (PYHIN) proteins are best known for their role in immune sensing and inflammasome activation. However, most studies …
WebJun 6, 2016 · Pyrin forms an inflammasome when mutant or in response to bacterial modification ... Casp1, Asc, Nlrp3, Nlrc4, Aim2, Mefv-deficient mice, or C-terminal pyrin … WebJun 23, 2024 · The five major inflammasomes (NLRP1, NLRP3, NLRC4, Pyrin, and AIM2) include cytoplasmic and nuclear sensor molecules that form a complex with the effector protein pro-caspase-1 8.
WebAIM2 is a pyrin and HIN (hematopoietic expression, interferon-inducible nature, and nuclear localization) domain–containing family member that directly binds cytosolic DNA. The …
WebResults: Obovatol inhibited NLRP3, AIM2, and non-canonical inflammasomes through inhibition of Asc pyroptosome formation and mitochondrial ROS generation. In addition, … multi centre holiday dealsWebApr 9, 2024 · AIM2 contains a DNA-binding hematopoietic expression, interferon-inducible nature, and nuclear localization (HIN) domain and a pyrin domain, which binds ASC. … how to measure cubic feet of microwaveWebApr 12, 2024 · AIM2 is another important inflammasome that can trigger a new kind of cell death called PANoptosis with ZBP1 and pyrin, resulting in respiratory infections from HSV1 and F. novicida. Colchicine, a drug inhibiting pyrin activation, can decrease the levels of cell death and the secretion of IL-β and IL-18. multi centre holiday italy 2023WebIn particular, Nod-like receptors containing a pyrin domain (PYD), called NLRPs, and AIM2-like receptors (ALRs) have been shown to play a critical role in host defense by f ... how to measure cross shoulderWebLike AIM2, IFI16 (IFN-inducible protein 16) belongs to the PYHIN (pyrin and HIN domain-containing) family. IFI16 in humans, and IFI204 the mouse orthologue, play an important role in regulating the production of IFN during both bacterial and viral infections. In contrast to AIM2, IFI16 is a nuclear DNA sensor. how to measure cultural changeWebSurprisingly, HIN2 of p202 interacts with the AIM HIN domain. We propose that this results in a spatial separation of the AIM2 pyrin domains, and indeed p202 prevented the dsDNA-dependent clustering of apoptosis-associated speck-like protein containing caspase recruitment domain (ASC) and AIM2 inflammasome activation. how to measure cubic inches of refrigeratorWebMar 21, 2024 · AIM2_HUMAN,O14862; Induction: By IFNG/IFN-gamma and IFNB1/IFN-beta. AIM2_HUMAN,O14862; EnzymeRegulation: In absence of dsDNA pyrin and HIN-20 domain can interact inducing a closed conformation; an autoinhibitory mechanism is proposed in which binding to dsDNA liberates the pyrin domain for homotypic … multicentre flights usa